New OTC - Generic Viagra Gel

A new competitor to generic Viagra, is an over the counter (OTC) gel developed by Futura Medical. GSK had recently entered into an agreement with Futura Medical to co-develop the drug for treatment of erectile dysfunction. If successful, the drug, MED2002, would be the world's first non-prescription pharmaceutical treatment for erectile dysfunction.

GSK Consumer Healthcare, is one of the world's largest over the counter pharmaceutical companies. Analysts are suggesting that the new gel will soon to roll out and become a blockbuster product in the burgeoning erectile dysfunction drug market.

There are currently are large range of very successful sublingual soft tabs, sildenafil citrate, tadalafil and vardenafil based formulations available. There are also a number of natural herbal ED stimulant products that have been in use for some time to increase libido. Prominent amongst the herbal Erectile Dysfunction medications is Libidus.

The new OTC gel, an invention of UK's leading sexual health company Futura Medical, would create huge competition in the erectile dysfunction drug market, which is a regulated prescription segment in most countries.

The ED market worldwide is dominated by Pfizer's Viagra and other 15 generic brands, many launched by Indian pharma majors. This is allowed to be prescribed only by specialists in cardiology, endocrinology and psychiatry in India.

Analysts believe when the GSK product is available in the OTC segment, it will open up a floodgate in India and in other countries, where these patients are often reluctant to have medical consultation.

The ED market in India is growing at more than 30 per cent with an estimated number of 12.5 million men suffering from various kinds of erectile dysfunction.

According to data cited by Futura, it is expected that the number of men with ED will double from its current level of 152 million worldwide to 322 million by 2025 due to ageing populations.
"It is too early to comment on the launch and the sales impact of this product in India though we are aware of the co-development programme by the parent company for the OTC Gel for erectyle dysfunction," said a GSK Consumer Healthcare India spokesperson.

Early this month, Paul Berman, vice-president of business development and strategic planning at GSK Consumer Healthcare Europe, was quoted by foreign media stating that; "This is a very exciting new business opportunity for GSK Consumer Healthcare, one that meets a significant unmet need in the marketplace, and the prospect to be the first regulatory approved non-prescription erectile dysfunction product is compelling."

Under the terms of the GSK-Futura agreement, GSK will pay 65 per cent of the clinical development program costs for the drug and Futura will pay the remaining 35 per cent.
The co-development program, to be run and managed primarily by GSK, is expected to comprise up to three studies involving approximately 1,500 men with ED and several additional safety studies to support the existing studies already completed by Futura. The drug is also likely to be human-tested in India as part of the global trials.

The agreement also includes license terms that are not yet legally binding, under which GSK would have global distribution and marketing rights for MED2002 as well as first refusal on two other products currently in the early stages of development: a non-prescription treatment for arousal and desire disorders associated with female sexual dysfunction and a non-prescription treatment for premature ejaculation.

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Can Viagra Improve Soldiers Performance in High Altitude combat zones?

A recent report in Sports Medicine Date: 25 Jun 2006 indicates results from a group of trained cyclists at high altitude shows that sildenafil citrate (Viagra) significantly improved the cardiovascular and exercise performance for some of the group.

The interesting variation between what would appear to be a consistent healthy group of cyclists measured the drugs effect, which boosted the performance of some participants up to a huge 45% -- while others showed little change. The sildenafil citrate provided no benefit at sea level.

Why did the drug work so effectively with some and not others? The basic analysis to date suggests that people who suffer most from a fall in their performance at high altitude are the most likely to benefit from sildenafil citrate. The results suggest that the responders experienced a greater degree of constriction of the vessels in the lungs at altitude and therefore benefited more from the vessel relaxation effects of sildenafil citrate.

Pfizer’s Viagra Drug sildenafil citrate expands the blood vessels :
Sildenafil citrate is best known as Viagra, a drug used to treat erectile dysfunction. Review DrugStoreBestBuys.com to see illustration of how sildenafil citrate works. The drug was originally developed to relieve high blood pressure. It causes blood vessels in certain tissues, such as the lungs, to relax. This improves blood flow from the heart and increases oxygen transport to working muscles. Because the high altitude atmosphere contains less oxygen, it is more difficult to get enough oxygen to support strenuous physical activity than it is at sea level.

Sildenafil works by inhibiting phosphodiestrase-5, an enzyme which degrades cyclic guanosine monophosphate (cGMP) a cell messenger that causes the blood vessels to relax, Friedlander explained. By inhibiting the enzyme, the drug allows greater vasodilation and greater blood flow.

Although the drug works in different target sites, this study focused on the lungs. The researchers hypothesized that the drug would allow the study's participants to improve their performance at altitude because it would reduce the constriction of vessels in the lungs that sometimes occurs at altitude. In turn, that would allow greater blood flow through the heart, better transfer of oxygen from the lungs to the blood and improved oxygen delivery to working muscles.

The participants, all trained cyclists, performed a total of 10 cycling trials, with and without sildenafil at sea level and at simulated altitude of 3,874 meters. Neither the participants nor the researchers knew whether the trial included a placebo or one of the two sildenafil doses, 50 mg or 100 mg. The high altitude simulation was achieved by changing the mix of air. The cyclists began breathing the high altitude mix starting one hour before the exercise session and continuing through the session. The simulation did not include the lower air pressure that would occur at altitude.

Researchers analyzed the changes in each individual's performance under various exercise conditions and also compared the group's performance under different drug conditions. Responders versus non-respondersFour of the 10 participants responded to sildenafil citrate while the remaining six did not, Friedlander said. The responders showed the greatest drops in stroke volume, cardiac output, and cycling performance between the sea level and high altitude trials without the drug. "Without sildenafil, their performance went down more than others," Friedlander said. "With it, it brought them back up to the levels of the non-responders."

The results suggest that the responders experienced a greater degree of constriction of the vessels in the lungs at altitude and therefore benefited more from the vessel relaxation effects of sildenafil citrate.

An outcome of the research work is the realisation that sildenafil citrate could be considered as a treatment for those who suffer most at altitude but, because of side effects that can include severe headaches and the apparent inability to help some people, it should not be taken as an exercise aid by everyone.

The bigger picture:
This study adds to the scientific knowledge of what physiological factors limit performance at altitude, including the role that cardiac output plays. For instance, physiologists don't know why some people have trouble at altitude and may develop illnesses such as acute mountain sickness or high altitude pulmonary edema while others adapt quickly.

Studies like this may help identify some of the underlying differences between people and lead to better treatments. In future studies, the researchers want to identify: * what steps individuals could take to acclimatize before they go to altitude* who is likely to acclimatize quickly at altitude and who may need additional help* how to minimize performance declines at altitude. There are some basic steps that improve the effectiveness of sildenafil citrate as discussed in DrugStoreBestBuys.com detailed resource papers.

The chief scientist Friedlander and her team are working on issues that could apply to those who have to rapidly acclimatize to high altitude. A topical example is when soldiers deploy to Afghanistan; they must quickly undertake physically taxing work at 12,000-14,000 feet, conditions that can severely affect performance under potentially life-threatening conditions.

In a study Friedlander and colleagues conducted at 14,000 feet on Pike's Peak, Colorado, participants showed marked hormonal changes at altitude. These changes facilitate oxygen delivery. However, this benefit is suppressed when individuals don't eat enough and the body shifts focus to store more energy, Friedlander explained. That study appears in the June issue of the American Journal of Physiology-Endocrinology and Metabolism, also published by APS.

Next steps One next step is to do a study with women, to see if they react the same way to sildenafil and altitude. The researchers also want to take a closer look at sildenafil responders to see if they can identify ahead of time who will benefit from treatment. In addition, a question still outstanding is whether non-responders would benefit from sildenafil at a higher elevation.

Source:
"Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia," by Andrew R. Hsu, Kimberly E. Barnholt and Nicolas K. Grundmann, Exercise Physiology Laboratory, Clinical Studies Unit, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA; Joseph H. Lin, Department of Medicine, Pulmonary and Critical Care, Stanford University School of Medicine; Stewart W. McCallum, Department of Urology, Stanford Medical Center; and Anne L. Friedlander, Exercise Physiology Laboratory, Clinical Studies Unit and Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care

Pharmacy Affiliates Watch Dog - Avoid Templates

Avoid or at least be wary of template sites offered by pharmacy affiliate programs.

Some unscrupulous Pharmacy programs use the lure of template sites. The template affiliate sites are very easy to split and hide the main source and cheap to rename, rebadge and put out there again to grab another set of affiliates.

A pharmacy that sells from its own site has to have more integrity, because the site is a public front that needs to maintain good standing. Affiliates can expect a longer term relationship with a supplier that has put time and money into a more public face. Customers and affiliates are able to deal directly with supplier which gives a better level of service.

When suppliers to template sites go down the affiliate drowns in customer complaints that are easily ignored by actual supplier. All sub affiliates signed up and 'lifetime' commissions also disappear often with a substantial amount of unpaid commission. There are many online pharmacy program sites listed by Pharmacy Shark Patrol as options to the bad programs

Beware affiliate programs and suppliers that hide behind you by getting you to set up your own template site.

Psychological Impotence

Researchers have identified two key types of Impotence also called Erectile Dysfunction. The two types are : a) Physical Impotence and b) Psychological Impotence.

It is thought that Physical Impotence affects up to 90 percent of all men who suffer from Erectile dysfunction. This form of Impotence can be remedied readily today with Erectile Dysfunction (ED) treatments.

The 10 percent of men that suffer mostly from psychological Impotence can now seek a number of different treatments. According to research, Psychological Impotence most often affects men during their first sexual interaction or when a man is undergoing some kind of emotional turmoil which leading to anger or stress.

If you are emotionally imbalance your sexual experience will always be obstructed because you’ll experience Impotence regularly. So, as soon as you experience problems with erection, you should consult a doctor to exclude any physical causes. If nothing is physically wrong, you have many other options.

Many men have discovered that a good medication for psychological Impotence is counseling especially if your partner is by your side throughout the procedure. Together with your partner you can find out whatever issues are causing you Impotence and learn how to cope with them.

For example, keeping your fear of performing well or keeping your anger buried inside may be expressing itself in the form of Impotence. In that case, counseling will help you understand why you are fearful or angry. you will learn skills and techniques to deal with your emotions and how to express them properly. You can see dramatic improvement after completing the session of counseling.

One of the most proven cures for Psychological Impotence in conjunction with counseling is medication. Apart from branded drugs such as Viagra, Levitra, and Cialis, the generic form of ED drugs are also of immense benefits. ED generic medicines such as Generic Viagra, Generic Cialis and Generic Levitra have been very successful in helping many men overcome Impotence.

Sometimes sufferers of diabetes may have a particular issue with standard ED drugs and may seek further information about ED medications which are specific to diabetes. Other fast acting sublingual (disolve under the tongue) ED pills work very rapidly and these are known as Soft Tabs , that are derived from Pfizer Viagra or alternatively a generic soft tab version

But you must always remember that like all drugs, these ED medications have side effects. That is why you should consult your healthcare provider before taking them. A detailed comparisons chart of the many ED medications can assist you to identify your options.

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Viagra may be used to treat Crohn's Disease

What possible connection does Viagra have with treatment of Crohn's Disease?

Crohn’s disease occurs mostly in the small intestine, in which segments become inflamed and the lining ulcerated, fissured and then greatly thickened. Between these affected segments the intestine remains normal. The condition commonly affects the lower part of the small intestine (the ileum), but can affect any part of the bowel.

Most treatments at present are topical. Acute inflammation is usually treated with applications applied directly into the back passage, such as foams or enemas containing corticosteroid drugs or compounds known as aminosalicylates, e.g. sulfasalazine or mesalazine to try and control the inflammatory process. If the disease does not respond to this local treatment, the same medicines are then taken by mouth as tablets, capsules or granules.

A recent study, which was primarily an investigation into the causes of Crohn's disease found an interesting outcome when Viagra was prescribed. Researchers studied the immune response to killed bacteria and acute trauma caused by biopsy of the bowel in individuals with Crohn's disease, ulcerative colitis, and non-inflammatory bowel disease. After injection with killed bacteria, patients with Crohn's disease showed an abnormally low increase in bloodflow at the site of the injection.

Ten individuals with Crohn's disease and five healthy individuals were given 50mg Viagra either 24 or 48 hours after bacterial injection. Most patients showed a significant increase in blood flow after taking Viagra. The authors concluded that vasodilatatory drugs such as Viagra may be useful in healing or preventing lesions in Crohn's disease. The results are preliminary and a clinical trial is needed before the effectiveness of Viagra in the treatment of Crohn's disease is known.

Updates in useful applications for Viagra and other Erectile Dysfunction drugs can be found in DrugStoreBestBuys.info

References and resources
1. Bowel disease researchers find Viagra could be a remedy.The Guardian, 24 February 2006, p24.
2. Marks DJB, Harbord MWN, MacAllister R, Rahman FZ, Young J, Al-Lazikani B, Lees W, Novelli M, Bloom S, Segal AW. Defective acute inflammation in Crohn's disease: a clinical investigation. British Medical Journal 2006;367; 668-678.

Avoid Viagra in sensitive neighbourhoods

A British couple are facing eviction from their neighbourhood following Viagra fuelled sex sessions in their home in Tyneside UK.

A mother of three who kept neighbours awake with noisy sex sessions after her boyfriend was prescribed Viagra is facing eviction.

Mum-of-three Michelle Butterfield and partner Darren Clarke have made life hell for residents on their Tyneside estate with their loud love-making and rows.

Today Mr Clarke said the noisy sessions had only started after he was prescribed Viagra by his doctor last year.

He has been banned from Butterfield's home and a court order has been issued banning her from allowing "noise audible outside the property".

Butterfield said she planned to fight the eviction proceedings which have been started against her. She said: "The neighbours have just ganged up on me, and I don't know why.

"One of my children's got attention deficit disorder and some of the noise comes from him, but that can't be helped.

"I've tried to sort it out with the neighbours, but I'll just have to fight them in court." Court papers in the case allege that Butterfield and Clarke have been responsible for a host of problems, especially since 2003.

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This site may help you overcome anxieties about using Viagra without keeping your neighbours awake at night.

Sex Drug Battles - Winners and Losers

The tussle for top dog status in the erectile dysfunction pill market continues.Sales and profit reports from the big 3 - Pfizer, Eli Lilly/ICOS and Bayer, show that Cialis is rapidly making up ground on Viagra, while the early growth of Levitra sales is levelling off.

The market shares over the last 12 month period to November 2005 show that Pfizer Viagra while down by 11% in market share, still dominates with a 60% impotency sex pill market share of a US 3 billion dollar market. Next comes Cialis with 25% a big jump up from 16%. Followed a distant third by Levitra up to 14% from 11 % last year.

The interesting fact is the $3 billion dollar market size accounted for by Pfizer Eli Lilly/ICOS and Bayer do not include the sale of either generic or herbal non pharmaceutical impotency boosting pills. Some analysts are suggesting the total market for the biggest blockbuster pills in history is a whopping US $5 to $6 Billion!!!

Has this put pressure on the big 3 manufacturers to make the ED pills more affordable in the biggest market of them all - USA? Not likely.The fight in suppressing generic erectile dysfunction treatments continues. Who is this fooling? Not many.

Recently the launch of Viagra in India was labelled a real flop. Even though Viagra is now available in India at substantially cheaper prices than in North America, the Indians' have shown they greatly prefer the Indian generic erectile dysfunction pills.

Also, peeping out from under the covers is the incredible growth in non traditional medicines like Libidus.

Has Pfizer realised too late that the rip off prices are unsustainable in a global economy? It is understood that the respected Indian pharmaceutical manufacturer, Ransbaxy spends a bigger percentage of their revenue on research than Pfizer. So let's not trot out that dead more research therefore higher prices argument as an excuse.

The issue is rip off pricing and the message is yet to overcome big pharma lobby groups before it can have an impact on American legislature.If generic pharmacies disappear then it's a no brainer to realise pharmacy prices will rocket up.A full review of online pharmacies is an interesting exercise to assist you to make up your own mind about who is doing the best job when it comes to public interest and service.