Viagra may be used to treat Crohn's Disease
What possible connection does Viagra have with treatment of Crohn's Disease?
Crohn’s disease occurs mostly in the small intestine, in which segments become inflamed and the lining ulcerated, fissured and then greatly thickened. Between these affected segments the intestine remains normal. The condition commonly affects the lower part of the small intestine (the ileum), but can affect any part of the bowel.
Most treatments at present are topical. Acute inflammation is usually treated with applications applied directly into the back passage, such as foams or enemas containing corticosteroid drugs or compounds known as aminosalicylates, e.g. sulfasalazine or mesalazine to try and control the inflammatory process. If the disease does not respond to this local treatment, the same medicines are then taken by mouth as tablets, capsules or granules.
A recent study, which was primarily an investigation into the causes of Crohn's disease found an interesting outcome when Viagra was prescribed. Researchers studied the immune response to killed bacteria and acute trauma caused by biopsy of the bowel in individuals with Crohn's disease, ulcerative colitis, and non-inflammatory bowel disease. After injection with killed bacteria, patients with Crohn's disease showed an abnormally low increase in bloodflow at the site of the injection.
Ten individuals with Crohn's disease and five healthy individuals were given 50mg Viagra either 24 or 48 hours after bacterial injection. Most patients showed a significant increase in blood flow after taking Viagra. The authors concluded that vasodilatatory drugs such as Viagra may be useful in healing or preventing lesions in Crohn's disease. The results are preliminary and a clinical trial is needed before the effectiveness of Viagra in the treatment of Crohn's disease is known.
Updates in useful applications for Viagra and other Erectile Dysfunction drugs can be found in DrugStoreBestBuys.info
References and resources
1. Bowel disease researchers find Viagra could be a remedy.The Guardian, 24 February 2006, p24.
2. Marks DJB, Harbord MWN, MacAllister R, Rahman FZ, Young J, Al-Lazikani B, Lees W, Novelli M, Bloom S, Segal AW. Defective acute inflammation in Crohn's disease: a clinical investigation. British Medical Journal 2006;367; 668-678.
Crohn’s disease occurs mostly in the small intestine, in which segments become inflamed and the lining ulcerated, fissured and then greatly thickened. Between these affected segments the intestine remains normal. The condition commonly affects the lower part of the small intestine (the ileum), but can affect any part of the bowel.
Most treatments at present are topical. Acute inflammation is usually treated with applications applied directly into the back passage, such as foams or enemas containing corticosteroid drugs or compounds known as aminosalicylates, e.g. sulfasalazine or mesalazine to try and control the inflammatory process. If the disease does not respond to this local treatment, the same medicines are then taken by mouth as tablets, capsules or granules.
A recent study, which was primarily an investigation into the causes of Crohn's disease found an interesting outcome when Viagra was prescribed. Researchers studied the immune response to killed bacteria and acute trauma caused by biopsy of the bowel in individuals with Crohn's disease, ulcerative colitis, and non-inflammatory bowel disease. After injection with killed bacteria, patients with Crohn's disease showed an abnormally low increase in bloodflow at the site of the injection.
Ten individuals with Crohn's disease and five healthy individuals were given 50mg Viagra either 24 or 48 hours after bacterial injection. Most patients showed a significant increase in blood flow after taking Viagra. The authors concluded that vasodilatatory drugs such as Viagra may be useful in healing or preventing lesions in Crohn's disease. The results are preliminary and a clinical trial is needed before the effectiveness of Viagra in the treatment of Crohn's disease is known.
Updates in useful applications for Viagra and other Erectile Dysfunction drugs can be found in DrugStoreBestBuys.info
References and resources
1. Bowel disease researchers find Viagra could be a remedy.The Guardian, 24 February 2006, p24.
2. Marks DJB, Harbord MWN, MacAllister R, Rahman FZ, Young J, Al-Lazikani B, Lees W, Novelli M, Bloom S, Segal AW. Defective acute inflammation in Crohn's disease: a clinical investigation. British Medical Journal 2006;367; 668-678.
posted by Clive Wallace at
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